Cherian T, Steinhoff M C, Harrison L H, Rohn D, McDougal L K, Dick J
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
JAMA. 1994 Mar 2;271(9):695-7.
To investigate a cluster of invasive pneumococcal disease in children 8 to 26 months of age, using standard microbiological procedures and ribosomal DNA gene-restriction patterns to characterize the outbreak strain.
Outbreak investigation.
A family child-care home with six children in Baltimore, Md.
During an 8-day period, three of the six children in the family child-care home had febrile illnesses with pneumococcal bacteremia, and a fourth had purulent pneumococcal conjunctivitis. Type 12F Streptococcus pneumoniae was isolated from the four ill children and from the nasopharynges of the two healthy children. Ribotyping revealed all outbreak isolates had an identical ribotype pattern. Administration of rifampin to the children did not eradicate carriage of the organism.
Our data demonstrate that child care provides an opportunity for outbreak of invasive pneumococcal disease in young children. This observation suggests a need for increased alertness for clusters of pneumococcal disease in young children in child-care facilities and underscores the necessity for a pneumococcal vaccine that is effective in infants and young children.
采用标准微生物学方法和核糖体DNA基因限制性图谱对一株暴发菌株进行鉴定，调查8至26个月大儿童中的一群侵袭性肺炎球菌疾病病例。
暴发调查。
马里兰州巴尔的摩市一家有6名儿童的家庭日托所。
在8天时间里，这家家庭日托所的6名儿童中有3名出现发热性疾病并伴有肺炎球菌菌血症，第四名儿童患有化脓性肺炎球菌性结膜炎。从4名患病儿童以及2名健康儿童的鼻咽部分离出了12F型肺炎链球菌。核糖体分型显示，所有暴发菌株都有相同的核糖体分型模式。给儿童使用利福平未能清除该病菌的携带状态。
我们的数据表明，日托为幼儿侵袭性肺炎球菌疾病的暴发提供了机会。这一观察结果提示，需要提高对托幼机构中幼儿肺炎球菌疾病聚集病例的警惕性，并强调需要一种对婴幼儿有效的肺炎球菌疫苗。
