氟卡尼致死性中毒。

Fatal flecainide intoxication.

作者信息

Rogers C, Anderson D T, Ribe J K, Sathyavagiswaran L

出版信息

J Anal Toxicol. 1993 Nov-Dec;17(7):434-5. doi: 10.1093/jat/17.7.434.

DOI:10.1093/jat/17.7.434

Abstract

Two fatalities resulting from suicidal ingestion of flecainide are described. The decedents, ages 33 and 15, were otherwise healthy; both took their mothers' medications. In one case, from electrocardiographic data, there was found a high-grade conduction block with idioventricular rhythm. Blood and tissue samples from autopsy were analyzed for flecainide by gas chromatography/nitrogen-phosphorous detection and gas chromatography/mass spectrometry. Blood concentrations of 93.7 and 100 mg/L flecainide were found.

摘要

本文描述了两起因自杀性摄入氟卡尼而导致的死亡案例。两名死者年龄分别为33岁和15岁，生前身体健康，均服用了其母亲的药物。其中一例，根据心电图数据，发现存在高度房室传导阻滞并伴有心室自主节律。通过气相色谱/氮磷检测和气相色谱/质谱分析法对尸检采集的血液和组织样本进行氟卡尼分析。结果发现血液中氟卡尼浓度分别为93.7毫克/升和100毫克/升。