Paolini A G, McKenzie J S
University of Melbourne, Department of Physiology, Parkville, Australia.
Neuroscience. 1993 Dec;57(3):717-24. doi: 10.1016/0306-4522(93)90017-a.
The nucleus of the horizontal limb of the diagonal band, a component of the basal forebrain magnocellular complex affected in Alzheimer type dementia, supplies centrifugal innervation to the olfactory bulb. We have tested the hypothesis that horizontal limb of the diagonal band lesions will interfere with olfactory memory in a simple olfactory test paradigm. Lesions occupied a restricted volume, approximately 20%, of medial horizontal limb of the diagonal band. There was interference with habituation of investigation latency and duration, six and 16 days after lesioning. It is concluded that bilateral partial lesions of the medial nucleus of the horizontal limb of the diagonal band interfere with habituation memory for odours.
斜角带水平支核是基底前脑大细胞复合体的一个组成部分，在阿尔茨海默型痴呆中会受到影响，它向嗅球提供离心神经支配。我们在一个简单的嗅觉测试范式中检验了这样一个假设，即斜角带水平支损伤会干扰嗅觉记忆。损伤占据了斜角带内侧水平支约20%的有限体积。在损伤后的第6天和第16天，调查潜伏期和持续时间的习惯化受到了干扰。得出的结论是，斜角带水平支内侧核的双侧部分损伤会干扰对气味的习惯化记忆。
