The level of immunoglobulins in the small and large intestinal mucosa from children with ulcerative colitis.

In 42 children 4 to 16 years old with ulcerative colitis by using peroxidase method and monoclonal antibodies we evaluated the presence of immunoglobulin A, M, G, E in the mucosa of the large and small intestines. It was found that the distribution of immunoglobulins in the acute phase was similar in the intestinal segments studied, which supports the opinion that the whole intestine has a common immune system playing a major role in the pathogenesis of the disease.