Baskin P, Salamone J
Department of Psychology, University of Connecticut, Storrs 06269-1020.
Pharmacol Biochem Behav. 1993 Dec;46(4):793-7. doi: 10.1016/0091-3057(93)90203-6.
Two experiments were conducted to study the vacuous jaw movements induced in rats by acute administration of the monoamine-depleting agent reserpine. In the first experiment, different doses of reserpine (1.25, 2.5, and 5.0 mg/kg) were assessed for their ability to induce vacuous jaw movements. Acute administration of reserpine induced a dose-related increase in vacuous jaw movements, with the two highest doses being significantly different from the vehicle control. In the second experiment, interactions between 5.0 mg/kg reserpine and the dopamine agonist apomorphine were investigated. Coadministration of reserpine with the lowest dose of apomorphine (0.1 mg/kg) significantly increased vacuous jaw movements relative to reserpine alone. The two higher doses of apomorphine (0.5 and 1.0 mg/kg) significantly decreased vacuous jaw movements in reserpine-treated rats. These results demonstrate that vacuous jaw movements are induced by acute reserpine treatment in a dose-related manner. In addition, the interactions with apomorphine suggest that vacuous jaw movements are stimulated by decreases in dopamine release produced by low doses of apomorphine that are thought to have mainly presynaptic actions, but that these movements are decreased by higher doses of apomorphine that are known to act postsynaptically.
进行了两项实验，以研究单胺耗竭剂利血平急性给药诱导大鼠出现的空嚼运动。在第一个实验中，评估了不同剂量的利血平（1.25、2.5和5.0毫克/千克）诱导空嚼运动的能力。利血平急性给药导致空嚼运动呈剂量相关增加，其中两个最高剂量与溶剂对照组有显著差异。在第二个实验中，研究了5.0毫克/千克利血平与多巴胺激动剂阿扑吗啡之间的相互作用。与最低剂量的阿扑吗啡（0.1毫克/千克）共同给药时，相对于单独使用利血平，显著增加了空嚼运动。两个较高剂量的阿扑吗啡（0.5和1.0毫克/千克）显著减少了利血平处理大鼠的空嚼运动。这些结果表明，利血平急性处理以剂量相关方式诱导空嚼运动。此外，与阿扑吗啡的相互作用表明，低剂量阿扑吗啡（被认为主要具有突触前作用）导致多巴胺释放减少，从而刺激空嚼运动，但已知具有突触后作用的较高剂量阿扑吗啡会减少这些运动。
