Matray-Devoti J, Wagner G C
Department of Physiology and Neurobiology, State University, New Brunswick, NJ 08903.
Pharmacol Biochem Behav. 1993 Dec;46(4):923-5. doi: 10.1016/0091-3057(93)90223-g.
The effect of a beta-adrenoreceptor blocking agent on defensive aggression in mice was evaluated. Acute doses of d,l-propranolol (0.2, 0.4, 0.8, 1.6, 3.2, 6.4, and 12.8 mg/kg) were administered to male Rockland-Swiss mice prior to testing in a target-biting paradigm. Baseline conditions established a high target-biting rate low biting rate during a 15-s tone stimulus preceding the next shock. Every dose of propranolol increased target-biting rates above baseline during each interval with one exception: 0.4 mg/kg decreased the biting rate immediately after delivery of the tail shock. The overall increase in aggression observed following dosing with propranolol was not expected from a review of the clinical literature. These results are discussed in reference to propranolol's known effects on the brain serotoninergic systems and the use of an animal model of defensive aggression.
评估了一种β-肾上腺素能受体阻断剂对小鼠防御性攻击行为的影响。在采用目标咬啮范式进行测试之前，对雄性罗克兰-瑞士小鼠给予急性剂量的消旋普萘洛尔（0.2、0.4、0.8、1.6、3.2、6.4和12.8毫克/千克）。基线条件确定在下一次电击前15秒的纯音刺激期间目标咬啮率高、咬啮率低。除了0.4毫克/千克在尾部电击后立即降低咬啮率外，每剂普萘洛尔在每个间隔期间均使目标咬啮率高于基线水平。从临床文献回顾来看，服用普萘洛尔后观察到的攻击性总体增加是出乎意料的。参照普萘洛尔对大脑5-羟色胺能系统的已知作用以及防御性攻击的动物模型的使用对这些结果进行了讨论。
