Poli A, Palermo-Neto J
Braz J Med Biol Res. 1986;19(3):411-7.
We measured the aggressive behavior of isolated mice treated or not with d,1-amphetamine (6.0 mg/kg, ip) and injected with different doses of d,1-propranolol (10.0, 20.0 or 30.0 mg/kg, ip) or haloperidol (0.5 or 1.0 mg/kg). d,1-Amphetamine (6.0 mg/kg, ip) decreased the aggressiveness of the isolated mice and induced stereotyped behavior. Haloperidol antagonized amphetamine-induced stereotypy, increased the latency to the 1st attack and decreased duration of fighting and frequency of attacks in mice treated or not with amphetamine. d,1-Propranolol did not change stereotypy but decreased aggressiveness in a dose-dependent way, being more effective against aggression induced by isolation per se. These results are discussed in terms of the interference of the drugs with the activity of either catecholaminergic neurons or midbrain reticular formation. The latter effect seems to be the most likely explanation for the observed anti-aggressive effects of haloperidol and d-1, propranolol.
我们测量了单独饲养的小鼠的攻击行为，这些小鼠接受或未接受右旋苯丙胺（6.0毫克/千克，腹腔注射）处理，并注射了不同剂量的普萘洛尔（10.0、20.0或30.0毫克/千克，腹腔注射）或氟哌啶醇（0.5或1.0毫克/千克）。右旋苯丙胺（6.0毫克/千克，腹腔注射）降低了单独饲养小鼠的攻击性，并诱发了刻板行为。氟哌啶醇拮抗了苯丙胺诱导的刻板行为，增加了首次攻击的潜伏期，并减少了接受或未接受苯丙胺处理的小鼠的打斗持续时间和攻击频率。普萘洛尔没有改变刻板行为，但以剂量依赖的方式降低了攻击性，对单独饲养本身诱导的攻击更有效。根据药物对儿茶酚胺能神经元或中脑网状结构活性的干扰来讨论这些结果。后一种效应似乎是观察到的氟哌啶醇和普萘洛尔抗攻击作用的最可能解释。
