Denhardt D T, Feng B, Edwards D R, Cocuzzi E T, Malyankar U M
Department of Biological Sciences, Rutgers University, Piscataway, NJ 08855.
Pharmacol Ther. 1993 Sep;59(3):329-41. doi: 10.1016/0163-7258(93)90074-n.
The TIMPs play an important role in regulating the activity of the secreted metalloproteinases (collagenases, stromelysins, gelatinases). Two different TIMPS have been well characterized, each capable of inhibiting all tested eukaryotic metalloproteinases but showing specific binding to a particular gelatinase at a site distinct from the active site. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype of cancer cells.
金属蛋白酶组织抑制因子（TIMPs）在调节分泌型金属蛋白酶（胶原酶、基质溶解素、明胶酶）的活性中发挥重要作用。两种不同的TIMPs已得到充分表征，每种都能够抑制所有测试的真核金属蛋白酶，但在与活性位点不同的位点显示出与特定明胶酶的特异性结合。它们影响前金属蛋白酶的激活，并作用于调节细胞外基质的蛋白水解，特别是在组织重塑和炎症过程中。在某些细胞类型上，它们可表现出生长因子样活性，并且能够抑制癌细胞的致瘤和转移表型。
