Rodionov S V, Farber A Ia, Safonov M V, Butenko A V
Grud Serdechnososudistaia Khir. 1993 Nov-Dec(6):45-8.
Fibrinolytic therapy with streptokinase preparations was administered to 79 patients. Hemorrhagic, embolic, thrombotic, and allergic complications were observed over the course of therapy. Massive bleedings occurred in 3 (4%) patients, two of them died. Negligible hematomas at the site of vessel puncture were seen in 11 (14.4%) cases. Distal arteries embolization developed in 6 (7.6%) patients. Nine patients (11.4%) developed early re-thromboses soon after therapy was over. Allergic reactions presenting as hyperthermia and short-term chill were observed in one third of the patients. Measures to prevent possible complications of fibrinolytic therapy are strict adherence to thrombolysis methods and a dynamic laboratory monitoring over the course of therapy.
对79例患者使用链激酶制剂进行了纤维蛋白溶解治疗。在治疗过程中观察到出血、栓塞、血栓形成和过敏并发症。3例（4%）患者发生大量出血，其中2例死亡。11例（14.4%）病例在血管穿刺部位出现轻微血肿。6例（7.6%）患者发生远端动脉栓塞。9例（11.4%）患者在治疗结束后不久出现早期再血栓形成。三分之一的患者出现了表现为高热和短期寒战的过敏反应。预防纤维蛋白溶解治疗可能并发症的措施是严格遵守溶栓方法，并在治疗过程中进行动态实验室监测。
