Binding of nuclear proteins to transcription regulatory elements in selenium deficiency.
作者信息
Christensen M J, Pusey N W
机构信息
Department of Food Science and Nutrition, Brigham Young University, Provo, UT 84602.
出版信息
Biochim Biophys Acta. 1994 Feb 22;1225(3):338-41. doi: 10.1016/0925-4439(94)90015-9.
PMID:8312382
Abstract
Dietary selenium deficiency in rats increased binding of liver nuclear proteins to DNA regulatory sequences which activate transcription in response to oxidative stress. In contrast, binding to the activator protein-1 control sequence, which is inhibited by oxidation, was decreased in selenium deficiency.
摘要
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