Christensen M J, Pusey N W
Department of Food Science and Nutrition, Brigham Young University, Provo, UT 84602.
Biochim Biophys Acta. 1994 Feb 22;1225(3):338-41. doi: 10.1016/0925-4439(94)90015-9.
Dietary selenium deficiency in rats increased binding of liver nuclear proteins to DNA regulatory sequences which activate transcription in response to oxidative stress. In contrast, binding to the activator protein-1 control sequence, which is inhibited by oxidation, was decreased in selenium deficiency.
大鼠饮食中硒缺乏会增加肝核蛋白与DNA调控序列的结合，这些序列可响应氧化应激激活转录。相反，与受氧化抑制的激活蛋白-1控制序列的结合在硒缺乏时会减少。
