硒缺乏会降低硫氧还蛋白还原酶的活性。

Thioredoxin reductase activity is decreased by selenium deficiency.

作者信息

Hill K E, McCollum G W, Boeglin M E, Burk R F

机构信息

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

出版信息

Biochem Biophys Res Commun. 1997 May 19;234(2):293-5. doi: 10.1006/bbrc.1997.6618.

DOI:10.1006/bbrc.1997.6618

PMID:9177261

Abstract

Animal thioredoxin reductase is a selenoprotein. In this study, thioredoxin reductase activities in liver, kidney, and brain have been compared in rats fed selenium-deficient and control diets for 14 weeks following weaning. Selenium deficiency caused a decrease in thioredoxin reductase activity from control to 4.5% in liver and 11% in kidney. However, brain thioredoxin reductase activity was not affected by selenium deficiency of this severity. Gold inhibited thioredoxin reductase activity in the liver in a manner typical of its effect on selenoenzymes. Repletion of selenium-deficient rats with injections of selenium caused thioredoxin reductase activity to increase more rapidly in the liver than glutathione peroxidase activity but more slowly than selenoprotein P. These results indicate that thioredoxin reductase activity in liver and kidney is sensitive to selenium nutritional status but that brain thioredoxin reductase activity is less sensitive.

摘要

动物硫氧还蛋白还原酶是一种硒蛋白。在本研究中，对断奶后喂食缺硒饲料和对照饲料14周的大鼠的肝脏、肾脏和大脑中的硫氧还蛋白还原酶活性进行了比较。缺硒导致肝脏中硫氧还蛋白还原酶活性从对照水平降至4.5%，肾脏中降至11%。然而，这种严重程度的缺硒并未影响大脑中的硫氧还蛋白还原酶活性。金以其对硒酶典型的作用方式抑制肝脏中的硫氧还蛋白还原酶活性。给缺硒大鼠注射硒进行补充，导致肝脏中硫氧还蛋白还原酶活性比谷胱甘肽过氧化物酶活性增加得更快，但比硒蛋白P增加得更慢。这些结果表明，肝脏和肾脏中的硫氧还蛋白还原酶活性对硒营养状况敏感，但大脑中的硫氧还蛋白还原酶活性较不敏感。