Smetana K
Department of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Biomaterials. 1993 Nov;14(14):1046-50. doi: 10.1016/0142-9612(93)90203-e.
This paper demonstrates the hydrophilic polymers (mainly based on hydroxyethyl methacrylate) as a tool of cell biology. They represent a favourable model for the study of the influence of the molecular design of polymers on (1) bioactive protein adsorption, (2) cell adhesion and/or (3) control of their function. The influence of the hydrophilic/hydrophobic properties of polymers and of the occurrence of charged functional chemical groups is able to influence the interaction of cells with these polymers. For example, the copolymer of hydroxyethyl methacrylate with sodium methacrylate (-COO- groups) is only little recognized by macrophages, which could be used in clinical implantology. It is shown that, similar to natural macromolecules of the extracellular matrix, the synthetic polymers are able to participate in the control of cell function.
本文展示了亲水性聚合物（主要基于甲基丙烯酸羟乙酯）作为细胞生物学工具的应用。它们是研究聚合物分子设计对（1）生物活性蛋白吸附、（2）细胞黏附及/或（3）其功能控制影响的良好模型。聚合物的亲水/疏水性质以及带电官能团的存在能够影响细胞与这些聚合物的相互作用。例如，甲基丙烯酸羟乙酯与甲基丙烯酸钠（含-COO-基团）的共聚物很少被巨噬细胞识别，可用于临床植入学。研究表明，与细胞外基质的天然大分子类似，合成聚合物能够参与细胞功能的控制。
