Arushanian E B, Beĭer E V
Biull Eksp Biol Med. 1993 Nov;116(11):513-5.
At night a more effective attenuation of sympathetic activity by acute and chronic propranolol was observed. Single use of the drug in other daytime was accompanied by irregular changes in the neuronal control of heart activities. This irregularity was intensified after repeated treatment of beta-adrenoblocker and led to the stable increase of the sympathetic tone in the morning and day hours.
夜间观察到急性和慢性使用普萘洛尔能更有效地减弱交感神经活动。在白天其他时段单独使用该药物会伴随心脏活动神经控制的不规则变化。在反复使用β-肾上腺素能阻滞剂后，这种不规则性加剧，并导致上午和白天交感神经张力持续升高。
