Arushanian E B, Beĭer E V
Eksp Klin Farmakol. 1994 Nov-Dec;57(6):22-4.
The main parameters and rhythmicity of the forced swimming, including the rhythmical index of depression, had great daily variations. The beta-adrenoblocker anapriline changed the temporal dynamics of swimming and decreased the depression index. The peak effect was shown in the daytime after an acute administration of the drug. After chronic administration, the peak pharmacological activity changed during morning hours.
强迫游泳的主要参数和节律性，包括抑郁节律指数，存在很大的日变化。β-肾上腺素阻滞剂心得安改变了游泳的时间动态并降低了抑郁指数。急性给药后，在白天显示出峰值效应。长期给药后，峰值药理活性在早晨时段发生变化。
