Nadzhimutdinov K N, Mavlianov I R, Umarov E F, Mutalov N K
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):28-30.
The antenatal use of nicotinamide and especially alpha-tocopherol in the experiments with premature newborn rats caused a significant decrease in the rate of lipid peroxidation and an increase in catalase activity both in the maternal body and in fetal lung tissue. It is suggested that the drugs can be used to prevent the development of membrane-destructive processes in the fetal and neonatal lung.
在早产新生大鼠实验中,产前使用烟酰胺尤其是α-生育酚,导致母体及胎儿肺组织中脂质过氧化速率显著降低,过氧化氢酶活性增加。提示这些药物可用于预防胎儿和新生儿肺中膜破坏过程的发展。