Prozorovskiĭ V B
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):43-5.
The application of the following new indices of the efficacy of antidotes has been substantiated and discussed: the "antidotal potency" as a ratio of LD50 of a poison when an antidote used to LD99 in control intact animals, and the "index of solid protection" as a ratio of LD10 in the experiments to LD90 in controls. The two indices are true for changing the lethality curve slope, which makes it impossible to use the currently accepted "protection index" as a ratio of LD50 in experiments to LD50 in controls.
“解毒效力”，即使用解毒剂时毒物的半数致死量（LD50）与对照未处理动物的99%致死量（LD99）之比；以及“可靠保护指数”，即实验中的10%致死量（LD10）与对照中的90%致死量（LD90）之比。这两个指标对于改变致死率曲线斜率是有效的，这使得无法使用目前公认的“保护指数”，即实验中的半数致死量（LD50）与对照中的半数致死量（LD50）之比。
