Janvier G, Caix J, Bordenave L, Revel P, Baquey C, Ducassou D
INSERM U. 306, Université de Bordeaux II, France.
Appl Radiat Isot. 1994 Feb;45(2):207-18. doi: 10.1016/0969-8043(94)90013-2.
The haemocompatibility of a vascular prosthesis can be estimated as the result of its interaction with blood components. The authors describe an ex vivo canine shunt for evaluating isotopic haemocompatibility in blood-wall interactions. Methods employing radioisotopic tracers can be used to dynamically monitor the adsorption of labelled blood cells and proteins on different biomaterial surfaces. This ex vivo test should enable materials to be assessed for quality according to two thrombogenic criteria: (i) number of adhered platelets mm-2 s-1; (ii) quantity of adsorbed fibrinogen expressed as microgram mm-2 s-1, which would provide the basis for a scale of haemocompatibility.
血管假体的血液相容性可作为其与血液成分相互作用的结果来评估。作者描述了一种用于评估血液-管壁相互作用中同位素血液相容性的体外犬类分流装置。采用放射性同位素示踪剂的方法可用于动态监测标记血细胞和蛋白质在不同生物材料表面的吸附情况。这种体外试验应能根据两个血栓形成标准对材料质量进行评估：（i）每平方毫米每秒粘附血小板的数量；（ii）以每平方毫米每秒微克表示的吸附纤维蛋白原的量，这将为血液相容性分级提供依据。
