Baquey C, Basse-Cathalinat B, Bordenave L, Caix J, Brendel A J, Ducassou D
Artif Organs. 1986 Dec;10(6):481-8. doi: 10.1111/j.1525-1594.1986.tb02608.x.
Functional investigations using radionuclides to study protein adsorption and platelet adhesion onto biomaterials are described. The authors' novel methods use radiotracers with a dynamic technique. This allows direct observation of the interaction between blood, or simpler biological substances, and artificial materials. Several radiotracers were used in this study, including 111In-platelets, 123I-fibrinogen, 123I-antithrombin III, and 99mTc-tagged red blood cells. The detectors employed were a semiconductor diode or gamma-camera equipped with special collimators. The acquisition and treatment of data were performed with an original device. These methods allowed precise comparisons, especially between platelet adhesion upon different materials in the form of tubes and also protein adsorption and desorption. The results are discussed in terms of materials to be used for work in vivo.
描述了使用放射性核素研究蛋白质吸附和血小板在生物材料上黏附的功能研究。作者的新方法采用带有动态技术的放射性示踪剂。这使得能够直接观察血液或更简单的生物物质与人工材料之间的相互作用。本研究使用了几种放射性示踪剂，包括铟 - 111标记的血小板、碘 - 123标记的纤维蛋白原、碘 - 123标记的抗凝血酶III以及锝 - 99m标记的红细胞。所使用的探测器是配备特殊准直器的半导体二极管或伽马相机。数据的采集和处理通过一台原始设备进行。这些方法能够进行精确比较，特别是不同材料制成的管状物上血小板黏附情况之间的比较，以及蛋白质的吸附和解吸情况。根据用于体内研究的材料对结果进行了讨论。
