Villares J, Faucheux B, Strada O, Hirsch E C, Agid Y, Javoy-Agid F
Laboratoire de Médecine Expérimentale, INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Brain Res. 1993 Nov 19;628(1-2):72-6. doi: 10.1016/0006-8993(93)90939-k.
Epidermal growth factor (EGF) is assumed to act as a neurotrophic factor on dopaminergic nigrostriatal neurons in cell cultures and animal brain. This led us to consider its possible role in the pathophysiology of Parkinson's disease. An autoradiographic study of the distribution of EGF-binding sites was performed in the mesencephalon of controls and patients with Parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. Scatchard analysis revealed a single type of binding sites with a high affinity constant, in the various mesencephalic dopaminergic areas examined. The characteristics and density of [125I]EGF-binding sites were similar in controls and parkinsonian patients. This suggests that EGF receptors in the mesencephalon are unaffected in Parkinson's disease and may therefore contribute to the increased activity and survival of the remaining dopaminergic neurons.
表皮生长因子（EGF）被认为在细胞培养和动物大脑中对多巴胺能黑质纹状体神经元起神经营养因子的作用。这使我们考虑其在帕金森病病理生理学中的可能作用。我们对对照组和帕金森病患者的中脑进行了EGF结合位点分布的放射自显影研究，帕金森病是一种与中脑纹状体多巴胺能神经元严重受损相关的神经退行性疾病。Scatchard分析显示，在所检查的各个中脑多巴胺能区域中，存在一种具有高亲和力常数的单一类型结合位点。对照组和帕金森病患者中[125I]EGF结合位点的特征和密度相似。这表明中脑中的EGF受体在帕金森病中未受影响，因此可能有助于剩余多巴胺能神经元活性增加和存活。
