Faucheux B A, Hauw J J, Agid Y, Hirsch E C
INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Brain Res. 1997 Feb 21;749(1):170-4. doi: 10.1016/s0006-8993(96)01412-6.
The density of [125I]-diferric-transferrin binding sites was investigated at the cellular level on melanized neurons located in the mesencephalon of patients with Parkinson's disease and control subjects, using quantitative autoradiography of in vitro incubated brain sections. In parkinsonian patients mean densities were reduced, the difference being statistically significant for the ventral tier of the substantia nigra, which is the subregion most affected by neuronal death in the disease. The absence of increase in the number of transferrin receptors on the perikarya within a population of neurons accumulating iron probably reflects the post-transcriptional gene regulation of the number of transferrin receptors that depends upon iron content in eukaryote cells.
利用体外孵育脑切片的定量放射自显影技术，在细胞水平上研究了帕金森病患者和对照受试者中脑黑素化神经元上[125I] - 二价铁转铁蛋白结合位点的密度。帕金森病患者的平均密度降低，黑质腹侧层的差异具有统计学意义，黑质腹侧层是该疾病中受神经元死亡影响最严重的亚区域。在积累铁的神经元群体中，其胞体上转铁蛋白受体数量没有增加，这可能反映了真核细胞中转铁蛋白受体数量的转录后基因调控取决于铁含量。
