Evans J L, Ng K H, Vonesh M J, Kramer B L, Meyers S N, Mills T A, Kane B J, Aldrich W N, Jang Y T, Yock P G
Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Ill.
Circulation. 1994 Feb;89(2):712-7. doi: 10.1161/01.cir.89.2.712.
Intravascular ultrasound (IVUS) of arteries is limited by the inability of current instruments to visualize beyond the catheter tip. We have developed a prototype 4-mm-diameter forward-viewing IVUS catheter (Cardiovascular Imaging Systems, Sunnyvale, Calif) that has the ability to provide B-mode cross-sectional ultrasound data for a distance of up to 2 cm distal to the catheter tip.
To study the utility of this device, a 20-MHz forward-viewing IVUS catheter was used to examine 13 arterial segments (5 human femoral arteries, 1 human carotid artery, 7 canine arteries) in vitro and 1 phantom. After imaging, all data were compared with histology (Histo). In all cases, the IVUS catheter provided forward-viewing images corresponding to the arterial geometry and demonstrated vascular landmarks and atherosclerotic lesions. There was a good correlation between Histo-determined luminal diameters (LD) and IVUS-determined diameters for a distance of 14 mm ahead of the catheter tip: IVUS LD = 1.0 Histo LD + 1.3 (r = .87).
These preliminary data suggest that a forward-viewing IVUS catheter is feasible, accurate, and useful for evaluation of arterial geometry distal to the catheter tip.
动脉内血管超声（IVUS）受限于当前仪器无法在导管尖端以外进行可视化观察。我们研发了一种直径4毫米的前视IVUS导管原型（心血管成像系统公司，加利福尼亚州森尼韦尔市），该导管能够在导管尖端远端最多2厘米的距离内提供B型横截面超声数据。
为研究该设备的实用性，使用了一根20兆赫的前视IVUS导管在体外检查13个动脉节段（5条人股动脉、1条人颈动脉、7条犬动脉）以及1个模型。成像后，将所有数据与组织学检查结果（Histo）进行比较。在所有病例中，IVUS导管均提供了与动脉几何形状相对应的前视图像，并显示出血管标志和动脉粥样硬化病变。在导管尖端前方14毫米的距离内，组织学测定的管腔直径（LD）与IVUS测定的直径之间存在良好的相关性：IVUS LD = 1.0×Histo LD + 1.3（r = 0.87）。
这些初步数据表明，前视IVUS导管对于评估导管尖端远端的动脉几何形状是可行、准确且有用的。
