Carroll B J
Department of Psychiatry, Duke University Medical Center, Durham, NC.
Clin Chem. 1994 Feb;40(2):303-8.
Manic depressive illness (bipolar disorder) is the mood disorder classically considered to have a strong biological basis. During manic depressive cycles, patients show dramatic fluctuations of mood, energy, activity, information processing, and behaviors. Theories of brain function and mood disorders must deal with the case of bipolar disorder, not simply unipolar depression. Shifts in the nosologic concepts of how manic depression is related to other mood disorders are discussed in this overview, and the renewed adoption of the Kraepelinian "spectrum" concept is recommended. The variable clinical presentations of manic depressive illness are emphasized. New genetic mechanisms that must be considered as candidate factors in relation to this phenotypic heterogeneity are discussed. Finally, the correlation of clinical symptom clusters with brain systems is considered in the context of a three-component model of manic depression.
躁郁症（双相情感障碍）是一种经典地被认为具有强大生物学基础的情绪障碍。在躁郁症发作周期中，患者会出现情绪、精力、活动、信息处理及行为的剧烈波动。脑功能和情绪障碍的理论必须应对双相情感障碍的情况，而不仅仅是单相抑郁症。本综述讨论了关于躁郁症与其他情绪障碍如何关联的疾病分类概念的转变，并建议重新采用克雷佩林的“谱系”概念。强调了躁郁症多变的临床表现。讨论了必须被视为与这种表型异质性相关的候选因素的新遗传机制。最后，在躁郁症的三分模型背景下考虑临床症状群与脑系统的相关性。
