Young A J, Hay J B, Mackay C R
Department of Immunology, Sunnybrook Health Science Centre, University of Toronto, Canada.
Curr Top Microbiol Immunol. 1993;184:161-73. doi: 10.1007/978-3-642-78253-4_13.
The physiological process of lymphocyte migration is a complex and dynamic process. The differential migration and life span of lymphocyte subsets is inherent to the normal function of the mammalian immune system. Adequate assessment of the involved processes requires the presence of an intact blood and lymphatic circulatory system and the ability to isolate individual tissues. The sheep provides an invaluable experimental model for studying these processes. Recent data suggest that direct quantitation of the life span of individual subsets of recirculating memory and naive lymphocytes is now possible, and that the long-term characterization of the behaviour of recirculating cells can be undertaken. Finally, it appears that previous qualitative data on tissue-specific homing pools can now begin to be understood in the context of phenotypic analysis for T cell markers and adhesion molecules, combined with long-term tracking techniques.
淋巴细胞迁移的生理过程是一个复杂且动态的过程。淋巴细胞亚群的差异性迁移和寿命是哺乳动物免疫系统正常功能所固有的。对相关过程进行充分评估需要完整的血液和淋巴循环系统以及分离单个组织的能力。绵羊为研究这些过程提供了一个极为宝贵的实验模型。最近的数据表明，现在有可能直接定量循环记忆淋巴细胞和初始淋巴细胞各个亚群的寿命，并且可以对循环细胞的行为进行长期表征。最后，似乎之前关于组织特异性归巢库的定性数据现在可以结合T细胞标志物和黏附分子的表型分析以及长期追踪技术来开始理解了。
