男性双胞胎高密度脂蛋白胆固醇（HDL）水平的LISREL模型

LISREL modeling of high density lipoprotein cholesterol (HDL) levels in male twins.

作者信息

Schwartz J E, Yuan H, Mendell N R, Finch S J

机构信息

State University of New York at Stony Brook 11794-8790.

出版信息

Genet Epidemiol. 1993;10(6):545-9. doi: 10.1002/gepi.1370100636.

DOI:10.1002/gepi.1370100636

PMID:8314058

Abstract

Based on the LISREL modeling approach for data from monozygotic (MZ) and dizygotic (DZ) twins [Heath et al., 1989; Neale and Cardon, 1992], the hypothesized variance of the logarithm of high density lipoprotein cholesterol due to additive genetic factors was estimated to equal 19% for males. Unobserved common environment accounted for 32% of the variance of log HDL. Both estimates controlled for body mass, alcohol consumption, and smoking. The model had very strong goodness-of-fit indices.

摘要

基于对同卵（MZ）和异卵（DZ）双胞胎数据的LISREL建模方法[希思等人，1989年；尼尔和卡登，1992年]，估计男性中由于加性遗传因素导致的高密度脂蛋白胆固醇对数的假设方差等于19%。未观察到的共同环境占对数高密度脂蛋白方差的32%。这两个估计值都对体重、饮酒量和吸烟情况进行了控制。该模型具有非常强的拟合优度指标。