回归模型在数量性状连锁分析中的应用。
Use of the regressive models in linkage analysis of quantitative traits.
作者信息
Demenais F, Lathrop M
机构信息
Unité de Recherche de Génétique des Maladies Humaines (INSERM U.358), Centre d'Etude du Polymorphisme Humain, Paris, France.
出版信息
Genet Epidemiol. 1993;10(6):587-92. doi: 10.1002/gepi.1370100643.
PMID:8314065
Abstract
Use of the regressive models to account for residual familial correlations in linkage analysis of complex quantitative traits can increase the power to detect linkage. This is especially observed when the effect of the gene to be mapped is small or when the residual correlations are substantial.
摘要
在复杂数量性状的连锁分析中，使用回归模型来解释残余家族相关性可提高检测连锁的效能。当待定位基因的效应较小或残余相关性较大时，尤其能观察到这种情况。
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