Hørding U, Junge J, Daugaard S, Lundvall F, Poulsen H, Bock J E
Department of Gynecology and Obstetrics, Rigshospitalet, University Hospital, Copenhagen, Denmark.
Gynecol Oncol. 1994 Feb;52(2):241-6. doi: 10.1006/gyno.1994.1039.
The vulvectomy specimens of 78 patients with vulvar squamous cell carcinoma were reviewed and examined for human papillomavirus (HPV) types 6, 11, 16, 18, and 33 by the polymerase chain reaction technique. The tumors were classified as keratinizing squamous cell carcinoma (KSC), as warty carcinoma (WC), and as basaloid carcinoma (BC). DNA of HPV types 16 and 33 was found in 2/51 KSC, in 12/17 WC, and in 10/10 BC. HPV types 6, 11, and 18 were not detected. Patients with WC and BC were younger, and 78% had VIN III lesions adjacent to the carcinoma. Patients with KSC were older and had a high incidence of dystrophic lesions, including lichen sclerosus, adjacent to the tumor. None of the KSC showed adjacent VIN III. In conclusion, vulvar carcinoma segregates into two categories, of which KSC seems to be the classic type, only rarely associated with HPV infection, and mostly affecting older women; WC and BC constitute an HPV-related subgroup of tumors occurring in younger patients and are associated with VIN III lesions from which they may emerge.
对78例外阴鳞状细胞癌患者的外阴切除术标本进行回顾，并通过聚合酶链反应技术检测人乳头瘤病毒（HPV）6、11、16、18和33型。肿瘤分为角化性鳞状细胞癌（KSC）、疣状癌（WC）和基底样癌（BC）。在51例KSC中的2例、17例WC中的12例和10例BC中的10例中发现了HPV 16和33型DNA。未检测到HPV 6、11和18型。WC和BC患者较年轻，78%的患者在癌旁有VIN III病变。KSC患者年龄较大，肿瘤旁营养不良性病变（包括硬化性苔藓）的发生率较高。KSC均未显示癌旁有VIN III。总之，外阴癌分为两类，其中KSC似乎是经典类型，很少与HPV感染相关，主要影响老年女性；WC和BC构成HPV相关的肿瘤亚组，发生于年轻患者，与它们可能起源的VIN III病变相关。
