不同方案的干扰素α-2b治疗慢性丙型肝炎的疗效
Efficacy of different regimens of interferon alfa-2b treatment in chronic hepatitis C.
作者信息
De Bac C, Grimaldi F, Clementi C, Duca F, Livoli D, Taliani G
机构信息
Viral Hepatology Service, La Sapienza University, Rome, Italy.
出版信息
Gut. 1993;34(2 Suppl):S135. doi: 10.1136/gut.34.2_suppl.s135.
Four different dosage regimens of interferon (IFN) alfa-2b (3 million units (MU) three times weekly for three months, 3 MU three times weekly for six months, 6 MU two times weekly for six months, and 6 MU three times weekly for six months) were compared in patients with chronic hepatitis C. There was no significant difference measured by percentage of responders to treatment between the four groups, but the degree of response was inversely correlated with the severity of liver damage. Viraemia was undetectable in most (75%) of responders treated with interferon and also in 20% of those who did not respond to treatment.
在慢性丙型肝炎患者中比较了四种不同剂量方案的干扰素（IFN）α-2b（每周三次，每次300万单位（MU），共三个月；每周三次，每次3MU，共六个月；每周两次，每次6MU，共六个月；每周三次，每次6MU，共六个月）。四组之间治疗反应者百分比的测量结果无显著差异，但反应程度与肝损伤严重程度呈负相关。在大多数（75%）接受干扰素治疗的反应者中以及20%未对治疗产生反应者中均未检测到病毒血症。
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