转化生长因子β1：α干扰素治疗的慢性丙型肝炎患者肝脏中的原位表达
Transforming growth factor beta 1: in situ expression in the liver of patients with chronic hepatitis C treated with alpha interferon.
作者信息
Bedossa P, Poynard T, Mathurin P, Lemaigre G, Chaput J C
机构信息
Laboratoire d'Anatomie Pathologique, Hôpital Antoine Beclere, Clamart, Paris, France.
出版信息
Gut. 1993;34(2 Suppl):S146-7. doi: 10.1136/gut.34.2_suppl.s146.
In a semiquantitative assessment of the expression of transforming growth factor (TGF) beta 1 in liver biopsy specimens from patients with chronic hepatitis C, treatment with interferon alfa-2b (3 million units (MU) three times weekly) decreased the expression of TGF beta 1 in six of seven patients. The reduction in TGF beta 1 correlated significantly with the scores for inflammation (p < 0.05) and necrosis (p < 0.05), but not with the alanine aminotransferase activities (p = 0.36) or the score for fibrosis (p = 0.86).
在对慢性丙型肝炎患者肝活检标本中转化生长因子（TGF）β1表达的半定量评估中，用α-2b干扰素（300万单位（MU），每周三次）治疗使7例患者中的6例TGFβ1表达降低。TGFβ1的降低与炎症评分（p < 0.05）和坏死评分（p < 0.05）显著相关，但与丙氨酸转氨酶活性（p = 0.36）或纤维化评分（p = 0.86）无关。
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