Girolami A, Brunetti A, Patrassi G M
Am J Clin Pathol. 1977 Jan;67(1):57-60. doi: 10.1093/ajcp/67.1.57.
A Normotest (NT)-Thrombotest (TT) discrepancy is claimed to reflect the presence of coumarin-induced inhibitors or intravascular coagulation, or both. The results of this study indicate, however, that a significant NT-TT discrepancy is also present in all plasmas from patients who have congenital coagulation disorders of the prothrombin complex. None of these patients had received an anticoagulant or showed any sign of intravascular clotting; nevertheless the discrepancy observed was similar to that found in plasmas of coumarin-treated patients: average values were 0.437 and 0.450, respectively. As no inhibitor was present in the congenital coagulation disorders, except in hemophilia BM, the phenomenon does not appear to be specific for coumarin plasma. This indicates that the NT/TT discrepancy is a non-specific phenomenon that does not seem to provide any additional information about coumarin-treated patients compared with that obtainable by means of a simple prothrombin time test.
有一种说法认为，正常凝血试验（NT）-凝血酶试验（TT）的差异反映了香豆素诱导的抑制剂的存在或血管内凝血，或两者皆有。然而，本研究结果表明，在患有凝血酶原复合物先天性凝血障碍的患者的所有血浆中也存在显著的NT-TT差异。这些患者均未接受过抗凝治疗，也未表现出任何血管内凝血迹象；尽管如此，观察到的差异与香豆素治疗患者血浆中的差异相似：平均值分别为0.437和0.450。由于除了血友病B型外，先天性凝血障碍患者体内不存在抑制剂，因此该现象似乎并非香豆素血浆所特有。这表明NT/TT差异是一种非特异性现象，与通过简单的凝血酶原时间试验所能获得的信息相比，它似乎并不能为香豆素治疗患者提供任何额外信息。
