Girolami A, Patrassi G, Fabris F
Folia Haematol Int Mag Klin Morphol Blutforsch. 1977;104(2):283-93.
Exposure of plasma to glass for 60 minutes will cause a sharp, progressive shortening of Thrombotest clotting times in all congenital disorders of the prothrombin complex. On the other hand Normotest clotting times will change only slightly or moderately after the same glass activation. Consequently the Normotest-Thrombotest percentile discrepancy, quite marked at zero time, became progressively smaller. This behaviour is similar to that observed in a group of coumarin treated patients. These studies indicate that the Normotest/Thrombotest discrepancy does not allow any differentiation to be made between congenital coagulation disorders and coumarin induced defect. This is consistent with the non-specificity of the phenomenon.
血浆与玻璃接触60分钟会导致在所有凝血酶原复合物先天性疾病中，凝血酶检测的凝血时间急剧、逐渐缩短。另一方面，在相同的玻璃激活后，正常检测的凝血时间只会有轻微或中等程度的变化。因此，正常检测-凝血酶检测百分位数差异在零时相当显著，随后逐渐变小。这种行为与在一组接受香豆素治疗的患者中观察到的行为相似。这些研究表明，正常检测/凝血酶检测差异无法区分先天性凝血障碍和香豆素诱导的缺陷。这与该现象的非特异性是一致的。
