Girolami A, Patrassi O, Cella G
Folia Haematol Int Mag Klin Morphol Blutforsch. 1977;104(3):463-70.
Thrombotest clotting times of mixtures of coumarin plasmas and normal plasma yielded a patterm similar to that observed in mixtures of plasma with congenital coagulation disorders and normal plasma. The presence of 10 or 20% of test plasma in the mixture failed to affect the clotting times which resulted in normal limits. The only exception to this rule was the hemophilia BM plasma. In this case even the presence of 10-20% of patient plasma in the mixture caused a prolongation of the clotting time. This indicates that no inhibitor is present in coumarin plasmas and in the plasma of congenital coagulation disorders of the prothrombin complex save for hemophilia BM plasma which does contain an inhibitor.
香豆素血浆与正常血浆混合物的凝血酶试验凝血时间产生的模式，类似于在患有先天性凝血障碍的血浆与正常血浆混合物中观察到的模式。混合物中10%或20%的测试血浆的存在并未影响凝血时间，其结果仍在正常范围内。该规则的唯一例外是血友病B型血浆。在这种情况下，即使混合物中存在10%-20%的患者血浆，也会导致凝血时间延长。这表明除了确实含有抑制剂的血友病B型血浆外，香豆素血浆和凝血酶原复合物先天性凝血障碍的血浆中不存在抑制剂。
