Sadato N, Ibañez V, Deiber M P, Campbell G, Leonardo M, Hallett M
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA.
J Cereb Blood Flow Metab. 1996 Jan;16(1):23-33. doi: 10.1097/00004647-199601000-00003.
To study the effect of the repetition rate of a simple movement on the distribution and magnitude of neuronal recruitment, we measured regional CBF (rCBF) in eight normal volunteers, using positron emission tomography and 15O-labeled water. An auditory-cued, repetitive flexion movement of the right index finger against the thumb was performed at very slow (0.25 and 0.5 Hz), slow (0.75 and 1 Hz), fast (2 and 2.5 Hz), and very fast (3 and 4 Hz) rates. The increase of rCBF during movement relative to the resting condition was calculated for each pair of movement conditions. Left primary sensorimotor cortex showed no significant activation at the very slow rates. There was a rapid rise of rCBF between the slow and the fast rates, but no further increase at the very fast rates. The right cerebellum showed similar changes. Changes in the left primary sensorimotor cortex and the cerebellum likely reflect the effect of the movement rate. The posterior supplementary motor area (SMA) showed its highest activation at the very slow rates but no significant activation at the very fast rates. Changes correlating with those in the SMA were found in the anterior cingulate gyrus, right prefrontal area, and right thalamus. The decreases in CBF may reflect a progressive change in performance from reactive to predictive.
为研究简单运动的重复率对神经元募集分布和强度的影响，我们使用正电子发射断层扫描和15O标记水，测量了8名正常志愿者的局部脑血流量（rCBF）。以非常慢（0.25和0.5赫兹）、慢（0.75和1赫兹）、快（2和2.5赫兹）以及非常快（3和4赫兹）的速率进行右食指对拇指的听觉提示重复屈曲运动。针对每对运动条件计算运动期间相对于静息状态的rCBF增加量。左初级感觉运动皮层在非常慢的速率下未显示出明显激活。在慢速率和快速率之间rCBF迅速上升，但在非常快速率下没有进一步增加。右小脑显示出类似变化。左初级感觉运动皮层和小脑的变化可能反映了运动速率的影响。后辅助运动区（SMA）在非常慢的速率下显示出最高激活，但在非常快速率下没有明显激活。在前扣带回、右前额叶区域和右丘脑中发现了与SMA变化相关的变化。脑血流量的减少可能反映了从反应性到预测性表现的逐渐变化。
