大鼠中心静脉导管相关脓毒症的动态变化
Dynamics of central venous catheter-related sepsis in rats.
作者信息
Paston M J, Meguid R A, Muscaritoli M, Forbes B, Yang Z J, Meguid M M
机构信息
Department of Surgery, University Hospital, State University of New York Health Science Center, Syracuse 13210.
出版信息
J Clin Microbiol. 1993 Jun;31(6):1652-5. doi: 10.1128/jcm.31.6.1652-1655.1993.
To determine when catheter-related sepsis clears after removal of an infected central venous catheter (CVC) and when a new sterile CVC can be inserted without risk of recolonization, a catheter infected with 10(5) CFU of Staphylococcus epidermidis per ml was inserted into 40 Fischer 344 rats. Five control rats had sterile catheters. Insertion of an infected CVC was followed by a significant rise in leukocytes after 4 days and the presence of S. epidermidis in lungs, livers, spleens, kidneys, and the catheter tip, as examined by bacteriological assay. After the infected catheter was removed, the rat recovered from the induced catheter-related sepsis within 12 h. When a new sterile CVC was inserted into the femoral vein, the leukocyte count remained normal, and all catheter tips and tissue cultures were sterile 4 days later.
为了确定感染的中心静脉导管（CVC）拔除后导管相关败血症何时清除，以及何时可以插入新的无菌CVC而无再次定植风险，将每毫升感染10(5) 个表皮葡萄球菌菌落形成单位（CFU）的导管插入40只Fischer 344大鼠体内。5只对照大鼠插入无菌导管。插入感染的CVC后，4天后白细胞显著升高，通过细菌学检测发现肺、肝、脾、肾及导管尖端存在表皮葡萄球菌。拔除感染导管后，大鼠在12小时内从诱导的导管相关败血症中恢复。当将新的无菌CVC插入股静脉时，白细胞计数保持正常，4天后所有导管尖端和组织培养均无菌。
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