Rupp M E, Ulphani J S, Fey P D, Mack D
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Infect Immun. 1999 May;67(5):2656-9. doi: 10.1128/IAI.67.5.2656-2659.1999.
Biofilm production is thought to be a crucial factor in the ability of Staphylococcus epidermidis to produce a biomaterial-based infection. A rat central venous catheter (CVC)-associated infection model was used to assess the importance of biofilm production, mediated by polysaccharide intercellular adhesin/hemagglutinin (PIA/HA), in the pathogenesis of intravascular catheter-associated infection. PIA/HA-positive S. epidermidis 1457 was significantly more likely to cause a CVC-associated infection (71 versus 14%, P < 0.03) resulting in bacteremia and metastatic disease than its isogenic PIA/HA-negative mutant. These results confirm the importance of biofilm production, mediated by PIA/HA, in the pathogenesis of S. epidermidis experimental CVC-associated infection.
生物膜的产生被认为是表皮葡萄球菌引发基于生物材料感染能力的关键因素。采用大鼠中心静脉导管（CVC）相关感染模型，以评估由多糖细胞间黏附素/血凝素（PIA/HA）介导的生物膜产生在血管内导管相关感染发病机制中的重要性。与同基因PIA/HA阴性突变体相比，PIA/HA阳性的表皮葡萄球菌1457更易引发CVC相关感染（71% 对14%，P < 0.03），导致菌血症和转移性疾病。这些结果证实了由PIA/HA介导的生物膜产生在表皮葡萄球菌实验性CVC相关感染发病机制中的重要性。
