Bergstein J M
Am J Pathol. 1977 Sep;88(3):655-62.
A fibrin slide test was utilized to study cutaneous vascular plasminogen activator activity in normal rabbit, rat, monkey, and human skin and in rabbit skin following development of the local Shwartzman reaction and after substituting epsilon-aminocaproic acid for the preparatory injection of endotoxin in the local Shwartzman reaction. Cutaneous vascular plasminogen activator activity was also studied in rats after attempted induction of the local Shwartzman reaction following inhibition of fibrinolysis with epsilon-aminocaproic acid and/or pregnancy. Plasminogen activator activity was detected in vessels of normal rat, monkey, and human skin but was absent in skin from normal rabbits and rabbits with the local Shwartzman reaction. Intradermal injection of epsilon-aminocaproic acid failed to prepare for the local Shwartzman reaction. In the rat, which has greater cutaneous vascular plasminogen activator activity than the rabbit, inhibition of vascular activator with epsilon-aminocaproic acid and/or pregnancy failed to prepare for the local Shwartzman reaction. These studies indicate that although the markedly diminished level of cutaneous vascular plasminogen activator in the rabbit may be important in the pathogenesis of the local Shwatzman reaction, factors other than inhibition of fibrinolysis are also necessary for preparation of the reaction.
采用纤维蛋白平板试验研究正常兔、大鼠、猴和人皮肤以及兔皮肤在发生局部施瓦茨曼反应后，以及在局部施瓦茨曼反应中用ε-氨基己酸替代内毒素预注射后的皮肤血管纤溶酶原激活物活性。在用ε-氨基己酸抑制纤维蛋白溶解和/或妊娠后试图诱导大鼠局部施瓦茨曼反应后，也对大鼠的皮肤血管纤溶酶原激活物活性进行了研究。在正常大鼠、猴和人的皮肤血管中检测到纤溶酶原激活物活性，但正常兔和发生局部施瓦茨曼反应的兔的皮肤中未检测到。皮内注射ε-氨基己酸不能引发局部施瓦茨曼反应。在皮肤血管纤溶酶原激活物活性比兔高的大鼠中，用ε-氨基己酸和/或妊娠抑制血管激活物不能引发局部施瓦茨曼反应。这些研究表明，虽然兔皮肤血管纤溶酶原激活物水平明显降低可能在局部施瓦茨曼反应的发病机制中起重要作用，但引发该反应除了抑制纤维蛋白溶解外还需要其他因素。
