Bellù R, Ortisi M T, Scaglioni S, Agostoni C, Salanitri V S, Riva E, Giovannini M
Fifth Department of Pediatrics, University of Milano, Italy.
J Pediatr Gastroenterol Nutr. 1993 May;16(4):446-50. doi: 10.1097/00005176-199305000-00018.
The association between lipids and apoproteins and indices of fat patterning was assessed in a sample of school-age children of both sexes. The study included 361 children between 6 and 15 years of age in two urban centers in the Milan area. Ages, weights, and skin folds were recorded, and percentages of overweight and body mass index were derived. Total cholesterol (TC), high-density lipoprotein cholesterol (C-HDL), triglycerides (TRIGL), apoprotein A-I (apoA-I), and apoprotein B (apoB) were assayed. Low-density lipoprotein cholesterol (C-LDL) was calculated. The obese boys had significantly higher levels of TRIGL and apoB than nonobese boys. The obese girls had significantly higher TC, TRIGL, C-LDL, and apoB levels than the nonobese girls, but lower C-HDL. The LDL/apoB ratio was lower in obese than normal-weight boys. The subscapular/tricipital fold ratio (S/T) was correlated positively with TRIGL and inversely with C-HDL in boys, while in girls it was correlated with TRIGL and apoB. The subscapular/iliac fold ratio (S/I) was correlated with the C-LDL/apoB ratio only in girls. These data underline the importance of anthropometric parameters and indices of fat patterning in determining early cardiovascular risk factors.
在一组学龄儿童样本中评估了脂质、载脂蛋白与脂肪分布指标之间的关联。该研究纳入了米兰地区两个城市中心的361名6至15岁的儿童。记录了年龄、体重和皮褶厚度，并计算出超重百分比和体重指数。检测了总胆固醇（TC）、高密度脂蛋白胆固醇（C-HDL）、甘油三酯（TRIGL）、载脂蛋白A-I（apoA-I）和载脂蛋白B（apoB）。计算了低密度脂蛋白胆固醇（C-LDL）。肥胖男孩的TRIGL和apoB水平显著高于非肥胖男孩。肥胖女孩的TC、TRIGL、C-LDL和apoB水平显著高于非肥胖女孩，但C-HDL水平较低。肥胖男孩的LDL/apoB比值低于正常体重男孩。在男孩中，肩胛下/三头肌皮褶厚度比值（S/T）与TRIGL呈正相关，与C-HDL呈负相关，而在女孩中，它与TRIGL和apoB相关。肩胛下/髂嵴皮褶厚度比值（S/I）仅在女孩中与C-LDL/apoB比值相关。这些数据强调了人体测量参数和脂肪分布指标在确定早期心血管危险因素方面的重要性。
