Takahashi H, Hashimoto N, Kawasaki T, Kikuchi T, Uchiyama M
Department of Pediatrics, Niigata University School of Medicine, Japan.
Acta Paediatr Jpn. 1996 Dec;38(6):634-9. doi: 10.1111/j.1442-200x.1996.tb03722.x.
Body fat deposition was measured in overweight and non-overweight children using a bioelectrical impedance method, and its relationship with serum lipids and apolipoproteins was investigated in 90 overweight children (over 120% of their ideal weight) and 241 non-overweight children aged 10-15 years in Niigata Prefecture. The results were as follows. Overweight boys had significantly higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), atherogenic index (AI), RLP-cholesterol (RLP-C), apoA1, apoA2, apoB, apoC2, apoC3, apoE and the ratio of apoB to apoA1 than non-overweight boys. Overweight girls had significantly higher levels of TC, LDL-C, AI, remnant-like lopoprotein cholesterol (RLP-C), apoA2, apoB, apoC2, apoC3, apoE and the ratio of apoB to apoA1 than non-overweight girls. It has been reported that of all children studied 2.1% had higher levels of RLP-C than its upper limit known for adults (12 mg/dL). Of the overweight children in the present study, 4.4% had a high level of RLP-C whereas only 1.2% of non-overweight children had a high RLP-C level. No difference in the lipoprotein levels was found between overweight and non-overweight children. In both boys and girls, relative weight, body fat, skinfold thickness and body mass index (BMI) were correlated with the lipoprotein levels. Non-overweight boys whose body fat was over 20% had significantly higher levels of TC, LDL-C, apoA2, apoB, apoC2, apoE and apoB/A1 than those whose body fat was less than 20%. It was concluded that the measurement of body fat deposition, together with relative weight, was useful for detecting obesity and atherogenesity in Japanese school children.
采用生物电阻抗法测量超重和非超重儿童的体脂沉积，并在新潟县对90名超重儿童（超过理想体重的120%）和241名10 - 15岁的非超重儿童进行了体脂沉积与血脂及载脂蛋白关系的研究。结果如下。超重男孩的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、动脉粥样硬化指数（AI）、残粒样脂蛋白胆固醇（RLP-C）、载脂蛋白A1（apoA1）、载脂蛋白A2（apoA2）、载脂蛋白B（apoB）、载脂蛋白C2（apoC2）、载脂蛋白C3（apoC3）、载脂蛋白E（apoE）以及apoB与apoA1的比值均显著高于非超重男孩。超重女孩的TC、LDL-C、AI、残粒样脂蛋白胆固醇（RLP-C）、apoA2、apoB、apoC2、apoC3、apoE以及apoB与apoA1的比值均显著高于非超重女孩。据报道，在所有研究儿童中，2.1%的儿童RLP-C水平高于已知的成人上限（12mg/dL）。在本研究的超重儿童中，4.4%的儿童RLP-C水平较高，而非超重儿童中只有1.2%的儿童RLP-C水平较高。超重和非超重儿童的脂蛋白水平没有差异。在男孩和女孩中，相对体重、体脂、皮褶厚度和体重指数（BMI）均与脂蛋白水平相关。体脂超过20%的非超重男孩的TC、LDL-C、apoA2、apoB、apoC2、apoE和apoB/A1水平显著高于体脂低于20%的男孩。研究得出结论，体脂沉积测量与相对体重一起，有助于检测日本学龄儿童的肥胖和动脉粥样硬化风险。
