[急性呼吸窘迫综合征患者支气管肺泡灌洗术中血小板活化因子和肿瘤坏死因子-α的研究]

[Platelet activating factor and tumor necrosis factor-alpha in bronchoalveolar lavage fluid of patients with ARDS].

作者信息

Matsumoto K, Taki F, Kondo Y, Taniguchi H, Takagi K, Matsuzaki M, Kayahara H

机构信息

Second Department of Medicine, Nagoya University School of Medicine, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Mar;31(3):330-5.

PMID:8315901

Abstract

Platelet activating factor (PAF) and tumor necrosis factor alpha (TNF-alpha) were examined in the bronchoalveolar lavage fluid (BALF) of 21 ARDS patients to clarify the role of these factors in ARDS. Neutrophil percentages and albumin concentrations in the BALF of the ARDS group were markedly elevated compared with those in the control group (p < 0.01), showing a significant correlation (r = 0.596, p < 0.01). PAF was detected in 14 of 19 ARDS patients (237.5 +/- 86.0 pg/ml) and TNF-alpha was detected in 7 of 16 ARDS patients (24.9 +/- 13.6 pg/ml), whereas these factors were not detected in control subjects. Neither PAF nor TNF-alpha showed a significant correlation with neutrophil percentage, neutrophil number or albumin concentration. They do not seem to be contributing factors to the prognosis of ARDS patients. However the existence of PAF and TNF-alpha in the BALF of some ARDS patients suggests that they might play a role in the pathogenesis of ARDS.

摘要

检测了21例急性呼吸窘迫综合征（ARDS）患者支气管肺泡灌洗液（BALF）中的血小板活化因子（PAF）和肿瘤坏死因子α（TNF-α），以阐明这些因子在ARDS中的作用。与对照组相比，ARDS组BALF中的中性粒细胞百分比和白蛋白浓度显著升高（p < 0.01），呈显著相关性（r = 0.596，p < 0.01）。19例ARDS患者中有14例检测到PAF（237.5 +/- 86.0 pg/ml），16例ARDS患者中有7例检测到TNF-α（24.9 +/- 13.6 pg/ml），而对照组未检测到这些因子。PAF和TNF-α与中性粒细胞百分比、中性粒细胞数量或白蛋白浓度均无显著相关性。它们似乎不是ARDS患者预后的影响因素。然而，部分ARDS患者BALF中存在PAF和TNF-α表明它们可能在ARDS的发病机制中起作用。