Bavazzano P, Li Donni V, Baldasseroni A
U.O. Tossicologia Industriale PMP-USL, Firenze, FI.
Med Lav. 1993 Mar-Apr;84(2):115-20.
The paper reports the results of a quality assurance programme for routine biological monitoring of n-hexane exposure via measurement of its urinary metabolite 2.5-hexanedione. The programme involved a number of local occupational health services and was coordinated by the industrial toxicology laboratory in Florence. The analytical results show good agreement (68.6%, i.e., 46/67) between high urinary levels of 2.5-hexanedione (equal to or higher than an action level of 3.2 mg/l) and a relatively poor environmental situation at the workplace as reported by the local occupational health services. The fall in the number of 2.5-hexanedione values equal to or higher than the action level in the course of the study period (1990-1991) could be a result of the prevention measures taken. To confirm this hypothesis, 69 enterprises with at least 3 determinations in both 1990 and 1991 were selected. A 58% decrease in the mean 2.5-hexanedione value between 1990 and 1992 was observed in the group of enterprises (24) with at least one sentinel health event in 1990 (a value equal to or higher than 3.2 mg/l). In the group of enterprises with no sentinel health event in 1990, the mean 2.5-hexanedione values were practically unchanged. The authors stress the need for further studies to test the hypotheses based on the data obtained in this study.
该论文报告了一项质量保证计划的结果，该计划通过测量尿中代谢物2,5-己二酮对正己烷暴露进行常规生物监测。该计划涉及多个当地职业健康服务机构，并由佛罗伦萨的工业毒理学实验室协调。分析结果表明，尿中2,5-己二酮高水平（等于或高于行动水平3.2毫克/升）与当地职业健康服务机构报告的工作场所相对较差的环境状况之间具有良好的一致性（68.6%，即46/67）。在研究期间（1990 - 1991年），等于或高于行动水平的2,5-己二酮值数量的下降可能是所采取预防措施的结果。为证实这一假设，选取了69家在1990年和1991年都至少有3次测定的企业。在1990年至少有一次哨兵健康事件（值等于或高于3.2毫克/升）的企业组（24家）中，观察到1990年至1992年期间2,5-己二酮平均值得以58%的下降。在1990年没有哨兵健康事件的企业组中，2,5-己二酮的平均值基本没有变化。作者强调需要进一步研究以基于本研究获得的数据来检验这些假设。
