Garavoglia M, Borghi F, Bianco S, Mauthe Degerfeld M, Gentilli S, Gattolin A, Buracco P
Department of Surgery, University of Torinò, Turin, Italy.
Panminerva Med. 1993 Mar;35(1):28-32.
A small bowel loop was interposed, isoperistaltically or pouch-shaped between colon and rectum, (ileo-colon-rectoplasty) in 8 pigs to clarify whether the small intestine can push the semi-solid and septic content of the colon, and whether the function and morphology of the loop are modified with respect to the original. A radiographic and histologic study was performed 6 months after the operation. The structural modifications of the interposed small bowel consist of disappearance of folds, villous atrophy, superficial appearance of the glandular crypts, and, only in the isoperistaltic loop, hypertrophy of the muscular layers. Any modification in the morphologic aspect of the pouch has not been observed, as shown by the radiographic barium enema. Therefore the mucosa of the grafted ileum suffered an architectural change caused from the contact with the fecal material. The lack of structural modifications of the muscular layers and the dimensions of the above colon of the interposed ileal pouch represents an indirect proof of the correct function of reservoir ejection. The experimental results obtained confirm the applicability of this technique in the reconstruction of transit after wide resection of the left colon and rectum, for technical reasons, in man.
在8头猪身上，将一段小肠袢以等蠕动或袋状的方式置于结肠和直肠之间（回肠-结肠-直肠成形术），以阐明小肠是否能推动结肠内的半固体和感染性内容物，以及该肠袢的功能和形态相对于原始状态是否发生改变。术后6个月进行了影像学和组织学研究。置入的小肠的结构改变包括皱襞消失、绒毛萎缩、腺隐窝表面化，并且仅在等蠕动肠袢中出现肌层肥大。如钡剂灌肠造影所示，未观察到袋状结构在形态方面有任何改变。因此，移植回肠的黏膜因与粪便物质接触而发生了结构变化。置入的回肠袋的肌层缺乏结构改变以及上述结肠的尺寸，这间接证明了储袋排空功能正常。所获得的实验结果证实了该技术在因技术原因对人体左半结肠和直肠进行广泛切除后重建传输功能方面的适用性。
