Wramner L, Mjörnstedt L, Rydberg L, Olausson M
Department of Surgery, Sahlgrenska Hospital, University of Göteborg, Sweden.
Scand J Immunol. 1993 Jun;37(6):656-60. doi: 10.1111/j.1365-3083.1993.tb01679.x.
The cell-mediated immune response was studied, using mixed lymphocyte reactivity (MLR) and cell-mediated lympholysis (CML) tests, in patients with well-functioning kidney grafts from living donors at 6 and 12 months and at 2-5 years after transplantation. The patients were allocated to treatment with cyclosporin A (CyA) and prednisolone (group A) or with CyA, prednisolone and azathioprine (group B). The MLR towards a third party were in the range of that of untreated controls while the anti-donor activities were reduced after 6 months in both groups. The CML activities in group A towards a third party were in the range of that of untreated controls at all times, while the anti-donor activities were decreased. By contrast, the CML activities in group B towards a third party were decreased during the first year and were in the range of that of normal controls at 2-5 years. The anti-donor CML activities were low at all times in group B. In summary, the two CyA protocols allowed the induction of donor-specific unresponsiveness within the first post-transplant year. The anti-third party activities were low during the first post-transplant year in recipients with triple therapy but not in those without azathioprine.
利用混合淋巴细胞反应（MLR）和细胞介导的淋巴细胞溶解（CML）试验，对活体供肾移植功能良好的患者在移植后6个月、12个月以及2至5年时的细胞介导免疫反应进行了研究。患者被分为两组，A组接受环孢素A（CyA）和泼尼松龙治疗，B组接受CyA、泼尼松龙和硫唑嘌呤治疗。两组患者对第三方的MLR与未治疗的对照组相当，而两组的抗供体活性在6个月后均有所降低。A组对第三方的CML活性在所有时间点都与未治疗的对照组相当，但其抗供体活性降低。相比之下，B组对第三方的CML活性在第一年有所下降，在2至5年时与正常对照组相当。B组的抗供体CML活性在所有时间点都较低。总之，两种CyA方案在移植后的第一年内均可诱导供体特异性无反应性。三联疗法的受者在移植后的第一年内对第三方的活性较低，但未使用硫唑嘌呤的受者并非如此。
