Lau C S, McLaren M, Saniabadi A, Belch J J
University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Scand J Rheumatol. 1993;22(3):97-101. doi: 10.3109/03009749309099251.
Platelet activation may have a pathophysiological role in Raynaud's phenomenon (RP). However, previous studies have shown conflicting results. This may be related to patient selection and the choice of platelet function assay. In this study, we have assessed platelet function of 30 patients with severe RP with (n = 14) or without (n = 16) systemic sclerosis (SSc), using a whole blood platelet aggregation (PA) assay. Raynaud's medication or other drugs which may affect PA were stopped at least 2 weeks previously. Spontaneous whole blood PA and that induced by 0.5 microM adenosine diphosphate and 0.6 and 1 microgram/ml collagen were significantly increased in both groups of patients when compared with controls. There were no significant differences in PA between the 2 groups of patients. Using a more physiological assay, patients with severe RP, whether or not associated with SSc, were shown to have abnormally increased platelet activity. Hyperactive platelets may further impede blood flow in RP.
血小板活化可能在雷诺现象（RP）中具有病理生理作用。然而，先前的研究结果相互矛盾。这可能与患者的选择以及血小板功能检测方法的选择有关。在本研究中，我们使用全血血小板聚集（PA）检测法评估了30例重度RP患者的血小板功能，其中14例合并系统性硬化症（SSc），16例未合并SSc。至少在两周前停用了雷诺病药物或其他可能影响PA的药物。与对照组相比，两组患者的自发性全血PA以及由0.5微摩尔二磷酸腺苷和0.6及1微克/毫升胶原蛋白诱导的PA均显著增加。两组患者之间的PA无显著差异。使用更符合生理的检测方法显示，重度RP患者，无论是否合并SSc，血小板活性均异常增加。血小板活性过高可能会进一步阻碍RP患者的血流。
