雷诺现象患者的血小板异常聚集。
Abnormal platelet aggregation in patients with Raynaud's phenomenon.
作者信息
Biondi M L, Marasini B
机构信息
Clinica Medica V, Università degli Studi di Milano, Italy.
出版信息
J Clin Pathol. 1989 Jul;42(7):716-8. doi: 10.1136/jcp.42.7.716.
Platelet aggregation in vitro to several aggregating agents (serotonin (5-HT), adenosine diphosphate, adrenaline and collagen) was studied in 16 patients with primary and secondary Raynaud's phenomenon and compared with that in 13 normal volunteers. Platelets from patients with Raynaud's phenomenon had significantly greater responses to all the 5-HT concentrations tested (p less than 0.001 for 10 microM; p less than 0.01 for 1 microM; p less than 0.05 for 0.1 microM; p less than 0.02 for 0.025 microM) and to low doses of adenosine diphosphate (p less than 0.01 for 1 microM; p less than 0.02 for 0.5 microM) but normal responses to collagen, adrenaline, and high doses of adenosine diphosphate. Patients with secondary Raynaud's phenomenon were significantly more hypersensitive to 0.5 microM adenosine diphosphate than patients with primary Raynaud's phenomenon. In patients with secondary Raynaud's phenomenon there was a significant correlation between the extent of 5-HT aggregation and the duration of the disease. The finding that platelets from patients with Raynaud's phenomenon have enhanced responses to 5-HT and adenosine diphosphate, but normal responses to adrenaline and collagen, is consistent with a role for 5-HT in this disease.
对16例原发性和继发性雷诺现象患者的血小板在体外对几种聚集剂（血清素（5-羟色胺）、二磷酸腺苷、肾上腺素和胶原蛋白）的聚集情况进行了研究，并与13名正常志愿者进行了比较。雷诺现象患者的血小板对所有测试的5-羟色胺浓度（10微摩尔时p<0.001；1微摩尔时p<0.01；0.1微摩尔时p<0.05；0.025微摩尔时p<0.02）以及低剂量的二磷酸腺苷（1微摩尔时p<0.01；0.5微摩尔时p<0.02）有显著更强的反应，但对胶原蛋白、肾上腺素和高剂量的二磷酸腺苷反应正常。继发性雷诺现象患者对0.5微摩尔二磷酸腺苷的敏感性明显高于原发性雷诺现象患者。在继发性雷诺现象患者中，5-羟色胺聚集程度与疾病持续时间之间存在显著相关性。雷诺现象患者的血小板对5-羟色胺和二磷酸腺苷反应增强，但对肾上腺素和胶原蛋白反应正常，这一发现与5-羟色胺在该疾病中的作用相符。
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