内皮细胞损伤和血小板活化在原发性雷诺现象（RP）及继发于系统性硬化症的RP中的相对作用。

Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis.

作者信息

Silveri F, De Angelis R, Poggi A, Muti S, Bonapace G, Argentati F, Cervini C

机构信息

Department of Rheumatology, Ancona University, Ospedale A. Murri, Jesi, Italy.

出版信息

Scand J Rheumatol. 2001;30(5):290-6. doi: 10.1080/030097401753180372.

DOI:10.1080/030097401753180372

PMID:11727844

Abstract

OBJECTIVE

To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc.

METHODS

Endothelial derived ET-1, t-PA, PAI-1, and platelet derived beta-TG, PDGF, TGF-beta were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls.

RESULTS

A significative increase of ET-1, t-PA, PAI-1, TGF-beta, and beta-TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and beta-TG levels were observed in patients with primary RP vs controls.

CONCLUSIONS

These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.

摘要

目的

评估内皮细胞和血小板在原发性雷诺现象（RP）及系统性硬化症（SSc）继发的RP发病机制中的相对作用。

方法

检测了36例原发性RP患者、14例SSc继发RP患者以及30例年龄和性别匹配的对照者的内皮细胞源性内皮素-1（ET-1）、组织型纤溶酶原激活物（t-PA）、纤溶酶原激活物抑制剂-1（PAI-1），以及血小板源性β-血小板球蛋白（β-TG）、血小板衍生生长因子（PDGF）、转化生长因子-β（TGF-β）。