Ghadially F N, Thomas M J, Jabi M, Rippstein P
Canadian Reference Centre for Cancer Pathology, Ottawa Civic Hospital, Canada.
Ultrastruct Pathol. 1993 Mar-Apr;17(2):161-8. doi: 10.3109/01913129309084036.
During ultrastructural examination of a difficult to diagnose tumor, short spacing collagen fibrils (periodicity of banding, approximately 43.2 nm) and native collagen fibrils (periodicity of banding, approximately 53 nm) were found in dilated and vacuolated cisternae of rough endoplasmic reticulum and the perinuclear cistern. Original diagnoses from several histopathologists included alveolar soft part sarcoma, malignant fibrous histiocytoma, atypical fibroxanthoma, and myogenic tumor. The finding of intracisternal collagen (which is but a variety of intracellular collagen) led to the conclusion that this was a fibroblastic neoplasm. This, plus a review of the histologic findings, led to the diagnosis of proliferative fasciitis and myositis of childhood.
在对一例难以诊断的肿瘤进行超微结构检查时，在粗面内质网扩张和空泡化的池以及核周池中发现了短间距胶原纤维（条带周期约为43.2 nm）和天然胶原纤维（条带周期约为53 nm）。几位组织病理学家最初的诊断包括肺泡软组织肉瘤、恶性纤维组织细胞瘤、非典型纤维黄色瘤和肌源性肿瘤。池内胶原（这只是细胞内胶原的一种）的发现得出结论，这是一种成纤维细胞性肿瘤。这一点，再加上对组织学发现的回顾，最终诊断为儿童增殖性筋膜炎和肌炎。
