[The peptidergic mechanisms controlling specialized appetites and taste afferentation].

Were studied the peptidergic mechanisms of regulation of the specialized forms of alimentary behaviour, i.e. the "salt" and "carbohydrate appetites", and the control of taste afferentation in the process of sodium chloride and saccharose consumption. Saccharose consumption controlled with participation of cholecystokinin was found to be mediated by an increase of taste afferentation under the influence of this peptide. Specialized sodium chloride consumption is under the control of the peptides litorine and substance P and mediated by a selective intensification of taste afferentation under the influence of these peptides. Active immunization by litorin-albumin and substance P-albumin conjugates was carried out to gain a high level of endogenous antibodies to these peptides. Injections of capsaicin to newborn rats was done for a degeneration of the substance P-containing nerve fibers. The methods used confirmed the specific participation of these peptides in a systemic regulation of salt consumption and activity of the chemoreceptors of the tongue. Were analyzed the main principles of the peptidergic regulation of the specialized forms of alimentary behaviour and the role of chemosensory afferentation in a correction of the process of consumption of the substances.