Zamboni M, Armellini F, Turcato E, Todesco T, Bissoli L, Bergamo-Andreis I A, Bosello O
Institute of Internal Medicine, Policlinico di Borgo Roma, Verona, Italy.
Am J Clin Nutr. 1993 Jul;58(1):29-34. doi: 10.1093/ajcn/58.1.29.
This study evaluates effects of weight loss on regional fat distribution and compares waist-to-hip ratio (WHR) and computed tomography (CT) as methods of assessing body fat distribution in 16 premenopausal obese women (body weight 104.3 +/- 18.1 kg, WHR 0.84 +/- 0.08). Mean weight loss was 6.6 kg after 2 wk on a very-low-energy diet (VLED) and 16 kg after 14 additional weeks on a low-energy diet (LED). Visceral abdominal fat and sagittal diameter significantly decreased after both the VLED and LED. Subcutaneous abdominal fat decreased significantly only after the LED. WHR showed no significant reduction over the entire study period. The decrease in visceral fat after both the VLED and LED was greater than the decrease in subcutaneous fat. Changes in body weight over the entire study period correlated with initial body weight and with total and subcutaneous abdominal fat, but not with visceral abdominal fat. They also correlated with changes in subcutaneous abdominal fat, visceral abdominal fat, sagittal diameter, and WHR. In conclusion, weight loss is associated with changes in regional fat distribution. In premenopausal subjects weight loss correlates more closely with the amount of subcutaneous than visceral fat.
本研究评估了体重减轻对局部脂肪分布的影响，并比较了腰臀比（WHR）和计算机断层扫描（CT）作为评估16名绝经前肥胖女性（体重104.3±18.1 kg，WHR 0.84±0.08）体脂肪分布方法的效果。在极低能量饮食（VLED）2周后平均体重减轻6.6 kg，在额外14周的低能量饮食（LED）后体重减轻16 kg。VLED和LED后，内脏腹部脂肪和矢状径均显著降低。仅在LED后皮下腹部脂肪显著减少。在整个研究期间WHR无显著降低。VLED和LED后内脏脂肪的减少均大于皮下脂肪的减少。整个研究期间体重的变化与初始体重、腹部总脂肪和皮下脂肪相关，但与内脏腹部脂肪无关。它们还与皮下腹部脂肪、内脏腹部脂肪、矢状径和WHR的变化相关。总之，体重减轻与局部脂肪分布的变化有关。在绝经前受试者中，体重减轻与皮下脂肪量的相关性比与内脏脂肪的相关性更密切。
