Bremner J D, Scott T M, Delaney R C, Southwick S M, Mason J W, Johnson D R, Innis R B, McCarthy G, Charney D S
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.
Am J Psychiatry. 1993 Jul;150(7):1015-9. doi: 10.1176/ajp.150.7.1015.
The purpose of this study was to compare the memory function of patients with posttraumatic stress disorder (PTSD) to that of matched comparison subjects.
Vietnam veterans with combat-related PTSD (N = 26) were compared to physically healthy comparison subjects (N = 15) matched for age, race, sex, years of education, handedness, socioeconomic status, and alcohol abuse. Memory and intelligence were assessed with a battery of neuropsychological tests, including the Russell revision of the Wechsler Memory Scale, the Selective Reminding Test, and subtests of the Wechsler Adult Intelligence Scale-Revised (WAIS-R).
The PTSD patients scored significantly lower than the comparison subjects on the Wechsler Memory Scale logical memory measures for immediate recall (mean = 11.6, SD = 3.3 versus mean = 20.9, SD = 6.6) and delayed recall (mean = 8.0, SD = 3.3 versus mean = 17.8, SD = 6.4). The PTSD patients also scored significantly lower on the total recall, long-term storage, long-term retrieval, and delayed recall measures for the verbal component of the Selective Reminding Test and on the recall, long-term storage, long-term retrieval, and continuous long-term retrieval measures for the visual component of the Selective Reminding Test. There was no significant difference between the PTSD patients and comparison subjects in prorated full-scale IQ as measured by the WAIS-R.
Patients with PTSD may have deficits in short-term memory. Counseling and rehabilitation that address these deficits may be of value for PTSD patients.
本研究旨在比较创伤后应激障碍(PTSD)患者与匹配的对照受试者的记忆功能。
将与战斗相关的创伤后应激障碍的越南退伍军人(N = 26)与年龄、种族、性别、受教育年限、利手、社会经济地位和酒精滥用情况相匹配的身体健康的对照受试者(N = 15)进行比较。通过一系列神经心理学测试评估记忆和智力,包括韦氏记忆量表的拉塞尔修订版、选择性提醒测试以及韦氏成人智力量表修订版(WAIS-R)的子测试。
在韦氏记忆量表的即时回忆逻辑记忆测量(均值 = 11.6,标准差 = 3.3,对比均值 = 20.9,标准差 = 6.6)和延迟回忆(均值 = 8.0,标准差 = 3.3,对比均值 = 17.8,标准差 = 6.4)方面,PTSD患者的得分显著低于对照受试者。在选择性提醒测试的言语部分的总回忆、长期存储、长期检索和延迟回忆测量以及选择性提醒测试的视觉部分的回忆、长期存储、长期检索和连续长期检索测量方面,PTSD患者的得分也显著较低。通过WAIS-R测量的比例全量表智商,PTSD患者与对照受试者之间没有显著差异。
PTSD患者可能存在短期记忆缺陷。针对这些缺陷的咨询和康复对PTSD患者可能有价值。