Armstrong P J, Morton C P, Nimmo A F
Department of Anaesthetics, University of Edinburgh, Royal Infirmary.
Anaesthesia. 1993 May;48(5):382-6. doi: 10.1111/j.1365-2044.1993.tb07008.x.
In a double-blind, randomised study, we have examined the effects of the addition of pethidine 100 mg to 40 ml prilocaine 0.25% for intravenous regional anaesthesia in healthy volunteers. During intravenous regional anaesthesia the hand and forearm are isolated from the rest of the circulation and pethidine interaction with central opiate receptors does not occur. Pethidine increased the speed of onset and extent of sensory and motor block, reduced tourniquet and forearm pain, and subjectively improved the quality of the block. Pethidine has local anaesthetic action on peripheral nerves in vivo.
在一项双盲随机研究中，我们检测了在健康志愿者中，于40毫升0.25%丙胺卡因中添加100毫克哌替啶用于静脉区域麻醉的效果。在静脉区域麻醉期间，手和前臂与其余循环系统隔离，哌替啶不会与中枢阿片受体发生相互作用。哌替啶加快了感觉和运动阻滞的起效速度及程度，减轻了止血带和前臂疼痛，并且主观上改善了阻滞质量。哌替啶在体内对周围神经具有局部麻醉作用。
