Pitkänen M, Kyttä J, Rosenberg P H
Department of Anesthesiology, Helsinki University Central Hospital, Finland.
Anaesthesia. 1993 Dec;48(12):1091-3. doi: 10.1111/j.1365-2044.1993.tb07536.x.
In a double-blind, randomised study of patients scheduled for minor hand surgery 0.5% 2-chloroprocaine (n = 30) and 0.5% prilocaine (n = 30) in a volume of 40 ml were compared for intravenous regional anaesthesia. The onset of sensory and motor block and recovery of sensory block were determined, and the occurrence of side-effects was noted. Twenty-four patients in the 2-chloroprocaine group and 17 in the prilocaine group developed complete sensory block by 15 min after injection (p < 0.05). Complete recovery of sensation was faster after prilocaine (7.1 min) than 2-chloroprocaine (9.8 min) (p < 0.01). Venous irritation and/or urticaria after tourniquet release was observed on 10 occasions in those receiving 2-chloroprocaine and twice in those receiving prilocaine. An increase in heart rate of > 20% above control values occurred in three patients, all of whom had been given 2-chloroprocaine. Clinically, local anaesthetic properties of 0.5% 2-chloroprocaine and prilocaine were similar, but there were more side-effects with the former drug.
在一项针对计划进行小型手部手术患者的双盲随机研究中，对比了40毫升体积的0.5%氯普鲁卡因（n = 30）和0.5%丙胺卡因（n = 30）用于静脉区域麻醉的效果。测定了感觉和运动阻滞的起效时间以及感觉阻滞的恢复时间，并记录了副作用的发生情况。氯普鲁卡因组24例患者和丙胺卡因组17例患者在注射后15分钟时出现了完全感觉阻滞（p < 0.05）。丙胺卡因注射后感觉完全恢复的时间（7.1分钟）比氯普鲁卡因（9.8分钟）更快（p < 0.01）。接受氯普鲁卡因的患者中10次观察到止血带松开后出现静脉刺激和/或荨麻疹，接受丙胺卡因的患者中出现过2次。3例患者心率较对照值增加超过20%，所有这些患者均接受了氯普鲁卡因。临床上，0.5%氯普鲁卡因和丙胺卡因的局部麻醉特性相似，但前一种药物的副作用更多。
